Lorentz Center - Designing the Bodyplan: Developmental Mechanisms from 4 Jun 2007 through 8 Jun 2007
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    Designing the Bodyplan: Developmental Mechanisms
    from 4 Jun 2007 through 8 Jun 2007

 
4 June

Monday 4 June


12.00   Lunch at Gorlaeus canteen

13.10   Introduction Lorentz Center: Martje Kruk

13.20   Introduction to the workshop Tony Durston

 

Keynote lectures:
13.30   L. Wolpert: Left/right asymmetry for the main body axis

14.15   C. Stern:  Gastrulation through a primitive streak: cellular mechanics and signals
15.00   Tea

15.30   W. Gehring: Phenotypic Suppression and Posterior Prevalence

16.15   R. Keller: Control of cell movement in gastrulation

17.00   Wine and Cheese Party

 

Tuesday 5 June


Morning: Gradients and making the axial pattern
.

9.15     L. Wolpert: Chairman’s Introduction - Gradients in A - P patterning

9.30     S. Gaunt: Cdx gradients and the AP axis

10.00   M. Maden: Retinoid gradients and the AP axis  

10.30   Coffee

11.00   R. Korswagen: Wnt gradients and the AP axis                  

11.30   H. Spaink: The role of glycans during zebrafish embryogenesis

                           

12.00   Lunch at Gorlaeus canteen

13.30   Panel discussion
            L. Wolpert, S. Gaunt, M. Maden, R. Korswagen, H. Spaink, C Stern, A. Durston,

           

Questions:
- Does each of these molecules participate in generating a functional gradient in vivo?

- What are the individual functions of the different gradients?

- How do they relate to and interact with each other?

- How do they relate to and interact with other patterning modules? (Timers, Hox complexes, Somitogenesis)

 

13.50   Timing mechanisms in A- P patterning - Chair C. Stern

13.50   C. Stern: Chairman’s introduction

14.00   C. Stern: Making a brain: the role of timing in developmental decisions

14.30   A. Durston: Hox temporal colinearity in AP patterning

15.00   Tea

15.30   Panel discussion

            L. Wolpert, S. Gaunt, M. Maden, R. Korswagen, H. Spaink, C Stern, A. Durston,

           

Questions:

- Do all of these timers function in vivo?

- How do all they relate to gradients?

- How do they interact with each other?

- How do they relate to other patterning modules (Hox complexes, somitogenesis)

 

 

18.00   Boat trip leaving from Haven Leiden – bus departs 17.15
           
Return at Zijldijk Leiderdorp at 22.00 – bus departs 22.15

 

Wednesday 6 June


Hox genes in AP patterning

9.00     W. Gehring: Chairman’s Introduction: Hox functions; DNA binding, protein-protein interactions and signaling

9.30     A. Prochiantz: Homeoprotein transcription factors and signaling

10.00   Discussion

10.30 J. Woltering: Micro RNAs in the Hox clusters

11.00   coffee

11.30   Panel discussion

 

12.00   Lunch at Gorlaeus canteen

13.30   Panel discussion

            J. Gehring, A. Prochiantz, J. Woltering, C. Duboule, M. Richardson, J. Deschamps

 

Questions:

- Does hox colinearity (spatial? temporal?) have a role in AP patterning? What role?

- Does this relate to other AP mechanisms (gradients, timers, somitogenesis, etc.)?

- How do the different aspects of hox colinearity relate to each other?

- What role do the hox micro RNA’s play?
- What role does Prochiantz singnaling play?

- What are the functions of the different properties of Hox homeoproteins (DNA binding, protein-protein interactions, intercellular singaling. In the context of A – P patterning?)

 

14.30   The Hox Complexes

15.00   D. Duboule: Chairman’s Introduction

15.15   D. Duboule: Hox colinearity

15.45   M. Richardson: title TBA

16.05   Tea

16.35   J. Deschamps: Hox, Cdx and the genetics of axial extension and patterning in the mouse embryo

17.05   Panel discussion

            J. Gehring, A. Prochiantz, J. Woltering, C. Duboule, M. Richardson, J. Deschamps

 

Questions:
- Does hox colinearity have a role in AP patterning? What role?

- Does this relate to other AP mechanisms (gradients, timers, somitogenesis, etc.?)

- How do the different aspects of hoxcolinearity relate to each other?

- What role do the hox micro RNA’s play?
- What role does Prochiantz signaling play?
- What are the functions of the different properties of Hox homeoproteins (DNA binding, protein-protein interactions, intercellular signaling. In the context of A – P pattering?)

 

18.30   Free evening

 

Thursday 7 June


Somitogenesis and theoretical models

9.00     H. Meinhardt: Chairman’s Introduction

9.15     O. Pourquie: Somitogenesis

9.45     P. Hogeweg: Modelling body axis formation as a dynamic

out of equilibrium multilevel process

10.15   Coffee

10.45   S. Maree: Modelling the chick somitogenesis clock-to-wavefront

11.05   F. Galis: Evolutionary Novelties: interactions between genetics, development and selection

11.25  T. Resende: Notochord signaling. Effects on somite segmentation

 

12.00   Lunch at Gorlaeus canteen

 

13.15   H. Metz: Towards a synthesis between adaptive dynamics and Evo-Devo

13.35   H. Meinhardt: Models for the generation of the primary body axes of higher organisms

14.05   Panel discussion

            H. Meinhardt, O. Pourquie, P. Hogeweg, A. Maree, F. Galis, T. Resende, J. Metz

 

Questions:

- What is the mechanism of somitogenesis? How do the available models stand up?
- Is the clock/ wavefront model for somitogenesis substantiated? How does it translate to a molecular mechanism?

- What is the mechanism for distinguishing regions of the A – P axis in bilateria?
- How do the available models stand up?

 

 

Cell movement, growth and morphogenesis

15.00   Chairman’s introduction – R. Keller

15.15   O. Pourquie: Hox genes and morphogenetic movement

15.45   C. Weijer: Chemotaxis in gastrulation

16.15   M. Affolter: Chemotaxis in the developing Drosophila tracheal system

16.45   Panel discussion

            R. Keller, O. Pourquie, C. Weijer, M. Affolter, V. Wilson, E. Tzouanacou, G. Krens

 

Questions:

- What is the role of chemotaxix? How many chemotactic systems?
- What is the role of hox genes in cell movement control and growth control?

- What is the balance between chemical and mechanical signals regulating movement?

- Do all vertebrates have the same mechanism for movement control, growth control and axial extension?
- What is the role of stem cells?

 

18:00   BBQ at the Beach pavilion Zomers in KatwijkBus departs at 17:15

            Bus will take everybody back to Leiden (hotel & station) at 22.00

           

 

Friday 8 June


Cell movement, growth and morphogenesis

9.00     V. Wilson: A stem cell population in the developing axis

9.30     E. Tzouanacou: Clonal continuity and tissue segregation during gastrulation and axial elongation of the mouse embryo

10.00   G. Krens: Distinct functions for ERK1 and ERK2 in gastrulation cell migration processes during zebrafish embryogenesis

10.00   Panel discussion continued

10.20   Coffee

10.40   Panel and general discussion

12.00   Lunch at Gorlaeus canteen

13.00   End



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