Lorentz Center - Proteins killing tumor cells from 29 Oct 2007 through 2 Nov 2007
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    Proteins killing tumor cells
    from 29 Oct 2007 through 2 Nov 2007

Preliminary program

Monday 29 October


08:30 – 09:15            Arrival and Registration

09:15 – 09:25            Introduction by Mrs. Martje Kruk-de Bruin,

Executive Manager of the Lorentz Center


Session 1:    Molecular aspects of apoptotic and transforming processes in relation to tumor development and anticancer therapy


09:30 – 10:15            Mathieu Noteborn (Leiden, Netherlands)

Apoptosis & Cancer combined: an Introduction


Coffee break


10:45 – 11:30            Jason Arroyo (Boston, USA)

                                    The role of PP2A specific complexes in cell transformation


11:30 – 11:50            Dongjun Peng (Wuhan, China)

                                    Cellular transforming processes sensed by apoptin


11:55 – 12:15            Daniel Portsmouth (Vienna, Austria)

Replicating murine leukaemia virus-based vectors for cancer gene therapy




13:45 – 14:30            Farzin Farzaneh (London, UK)

                                    Gene Therapy – hype or hope


14:30 – 16:00            Discussions / Poster viewing


16:00 – 17:00            James Pipas (Pittsburg, USA)

Role of multiple domains of SV40 T antigen in gene regulation and transformation


17:00                          Wine and Cheese welcome party, common room of the  Lorentz Center



Tuesday 30 October


Session 2:    Apoptotic and tumor pathways sensed by TRAIL and MDA7 and HAMLET


09:30 – 10:30            Rajagopal Ramesh (Houston, USA)

                                    To kill or not to kill cancer cells: A perspective of MDA-7/IL-24


                                    Coffee break


11:00 – 11:45            Jannie Borst (Amsterdam, Netherlands)

                                    Mechanism of interaction between TRAIL and radiotherapy


11:45 – 12:15            Robbert Cool (Groningen, Netherlands)

Receptor-specific variants of cytokine TRAIL with improved apoptotic characteristics




13:45 – 14:30            Marek Los (Winnipeg, Canada)

                                    Brevinin-2R, a novel defensin with anticancer properties


14:30 – 16:30            Discussions / Poster viewing / Exhibition


16:30 – 17:30            Catharina Svanborg (Lund, Sweden)

                                    HAMLET, protein folding and tumor cell death


17:45                           Drinks and Dinner prepared by the Leiden division of Soroptimists: http://www.soroptimist.nl/html/index.php?sitedeelID=4

in the adjacent Gorlaeus Cantina


Wednesday 31 October


Session 3:    Tumor-related pathways sensed by viral NS1, Apoptin, E4orf4 leading to apoptosis


09:30 – 10:15            Josée Lavoie (Quebec, Canada)

                                    E4orf4, actin-based membrane dynamics and tumor cell death


                                    Coffee break


10:45 – 11:30            Mahvash Tavassoli (London, UK)

Specific and efficient killing of cancer cells by Apoptin: Overview of the group’s activity


11:30 – 11:50            Jun Sun (Wuhan, China)

                                    PTD4-apoptin protein therapy inhibits tumor growth in vivo


11:55 – 12:15            Jose Teodoro (Montreal, Canada)

Viral inhibition of the anaphase-promoting/cyclosome complex (APC/C) as a mechanism of inducing tumour-specific cell death




13:45 – 14:05            Joop Gaken (London, UK)

                                    TAT-Apoptin mediated induction of apoptosis in leukaemic cells


14:10 – 14:30            Joseph Cheng (Charleston, USA)

Modulation of sphingolipid metabolism enhances Apoptin’s cytotoxicity in prostate cancer


14:35 – 14:55            Paola Bruno (London, UK)

Exploring the mechanism of the tumour-specific phosphorylation and cytotoxicity of Apoptin


15:00 – 16:30            Discussions / Poster viewing


16:30 – 17:30            Jürg Nüesch (Heidelberg, Germany)

A novel viral adaptor protein modulating Casein Kinase II activity induces cytopathic effects in cancer cells


19:00                          Dinner at Malle Jan, Leiden Town Center


Thursday 1 November


Session 4:    Cellular responses in normal healthy cells to tumor-related changes


09:30 – 10:15            Michael Green (Worcester, USA)

Dissecting the Basis of Oncogene-Induced Senescence and Apoptosis through a Genome-Wide RNA Interference Screen


10:30 – 11:15            David Jans (Monash, Australia)

Tumor cell-specific nuclear targeting: Applications for CAV viral protein 3


Coffee break (short!)


11:30 – 12:15            Henning Walczak (Heidelberg, Germany)





13:45 – 14:05            Poramaporn Klanrit (London, UK)

                                    Role of p73 isoforms in the induction of cell death by Apoptin


14:05 – 14:25            Rhyenne Zimmerman (Leiden, Netherlands)

                                    Partners in crime: Apoptin-interacting-proteins (AIP’s)




14:30 – 15:45            OPEN SESSION

                                    Matters arising & selected poster presentations


Social event during the rest of the afternoon


17:00                          Departure Boat trip with Conference Dinner aboard

                                     from Leiden Harbour, down town

                                    Back at the quayside at 21:00 hrs.



Friday 2 November


Session 5:    Tools for dissecting form & function


09:30 – 10:15            Jan-Pieter Abrahams (Leiden, Netherlands)

                                    Protein structure & tumor-specific apoptosis


                                    Coffee break


10:45 – 11:15            Niels Galjart (Rotterdam, Netherlands)

Bio-imaging applied to the functional analysis of the insulator protein CTCF


11:30 – 12:15            Herman Spaink (Leiden, Netherlands)

                                    Zebrafish as a model for studying cancer and apoptosis




13:45 – 14:05            Johannes Van Beek (Amsterdam, Netherlands)                  

Deciding the behaviour of intracellular networks: Using integrative bioinformatics and computational systems biology


14:10 – 14:30            Maarten de Smit (Leiden, Netherlands)           

Improved yeast-two-hybrid system for working with proteins affecting yeast growth


14:45 – 16:00            ROUND TABLE & CONCLUSIONS




(some posters will be selected for the “Open Session” presentations on Thursday)


A.G. de Boer (Leiden)

A novel approach to deliver the Apoptin-gene to (brain) tumours


Marie-Chloe Boulanger (Quebec, Canada)

Actin Dynamics contribute to the Transformed- and Tumor Cell-selective Activity of Ad2 E4orf4


Marcella Flinterman (London, UK)

Development of a novel TAT-based protein transduction strategy for Apoptin delivery


Ingrid van Leeuwen (Amsterdam, Netherlands)

Combined fusicoccin and interferon-α treatment kills tumor cells by apoptosis induction


Muhammad Adeel Riaz (London)

Apoptin induced cell killing in Oral Cancer cell lines


Christel Rothe Brinkmann (Aarhus, Denmark)

Cytotoxic activity of a bovine a-lactalbumin:oleic acid complex


Marie-Claude Landry (Quebec, Canada)

A Role for Cdc42- and Rab11a-regulated endosome traffic in Caspase-independent

Golgi Disassembly and Cell Death

Astrid Visser (Leiden, Netherlands)

Apoptin-multimerization in vivo


Ying-Hui Zhang (Leiden)    

Apoptin senses cell-type specific nuclear trafficking of the SV40 transforming T antigens