|Current Workshop | Overview||Back | Print | Home | Search ||
Lorentz Center Highlights
Amyloid aggregation: unraveling a knotty problem
Vinod SubramaniamUniversity of Twente
ABSTRACT: Misfolding and aggregation of proteins into nanometer-scale fibrillar assemblies, called amyloid, is a hallmark of many neurodegenerative diseases. Although vastly different proteins can form structurally similar amyloid nanostructures, the underlying biophysical principles are incompletely understood. A particularly relevant question is the role of early oligomeric aggregates in the aggregation pathway, and in lipid membrane interactions. In this short presentation, I will summarize recent advances in understanding amyloid aggregation kinetics, the structures and compositions of oligomeric aggregates, and the interaction of amyloid with lipid membranes.