Lorentz Center

International center for scientific workshops

International center for scientific workshops

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## Mathematical Pharmacology |

Whilst the costs of pharmaceutical research and development have
only increased over the past decades, the productivity, i.e. the number of drugs
that is approved for therapeutic use per year, remains continuously in decline.
There is increasing awareness that the high level of biological complexity of
organisms, pathophysiological conditions, and our inability to capture those
features, are major obstacles to rationally design effective pharmacological
therapies. Systems pharmacology is an emerging scientific area that aims to
fill the gap between systems biology and pharmacology by integrating modelling
approaches. There is a diversity of challenges that still needs to be addressed
in order to maximally benefit from its potential to improve drug development
and therapeutics. Examples of such challenges are: i) multiple scales and the
integration between those scales; ii) integration of modelling approaches
outside differential equation-based models; iii) bridging between highly mechanistic
models that are too complex to apply in drug development. The use of mathematics, mathematical analysis
and mathematical modelling to perform such bridging and integration is
considered of critical importance to support such integration. As such, a <em>mathematical pharmacology</em>
approach has the potential to make a substantial impact to advance the field of
systems pharmacology and therefore ultimately to allow for improved rational
design of new therapeutic interventions with maximal therapeutic effect and
minimal adverse drug effects. This workshop aims to take a step towards the further development of mathematical
pharmacology by bringing together mathematicians and pharmacologists, from both
academia and industry, and stimulate discussions about the challenges and
opportunities when applying mathematical approaches in systems pharmacology. The
workshop will be focused (25 participants) and apart from a number of
presentations, there will be ample of time for discussions and interactions
amongst the participants [Back] |