Integrative Developmental Biology 2020
- Rescheduled -
21 - 25 September 2020
Venue: Oort
If you are invited or already registered for this workshop, you have received login details by email.Developmental biology has recently experienced a tremendous revival, due to its importance for regenerative medicine as well as powerful new methods. Progress is currently driven by recent breakthroughs in three areas: 1. the ability to quantify single-cell dynamics in embryos by novel microscopy and sequencing techniques, 2. the creation of synthetic developmental systems such as organoids and gastruloids, and 3. multiscale modeling approaches that combine biophysical and gene regulatory mechanisms. Integrating these innovations has the potential to provide a big leap forward in our understanding of development.
To achieve this goal, this workshop will bring together leading researchers across model systems and approaches and help them become aware of each other’s strengths. The central goal is to define new research questions that can only be addressed with input from all areas. Alternating between presentations and group discussions, the program is designed to stimulate new collaborations and crystallize a roadmap for integrative developmental biology.
Monday September 21
Integrative developmental biology – build, measure, model
Preliminary program
Day 1
Theme: it starts with a single cell
9:00-10:00 registration and coffee
10:00 - 10:30 welcome
10:30-11:30 Keynote (single-cell methods) - Measure
11:30-12:15 Invited talk (synthetic transcription factor networks) - Build
12:15-13:30 Lunch and sponsor presentation (GenomeScan, single-cell sequencing)
13:30-14:15 Invited talk (gene regulatory networks) - Model
14:15-15:45 3 contributed talks
Big question: What is a cell type?
15:45 - 16:30 Break-out discussions on sub-questions
16:30 - 17:00 Plenary discussion of break-out results
17:00-19:00 Wine and cheese party
Tuesday September 22
Day 2
Theme: let's get together - tissues
9:00-10:00 keynote (gastruloids) - Build
10:00-10:45 invited talk (live cell tracking) - Measure
10:45-11:15 break
11:15-12:00 invited talk (agent-based modeling) - Model
12:00-12:30 contributed talk
12:30-14:00 Lunch and sponsor presentation (organoid culture)
14:00-15:30 3 contributed talks
Big question: How does tissue-level organization emerge from single-cell dynamics?
15:30-16:15 Break-out discussions on sub-questions
16:15-17:00 Plenary discussion of break-out results
17:00-18:00 Poster session 1
Wednesday September 23
Day 3
Theme: getting organized - signals, gradients, forces
9:00-10:00 Keynote (2D models) - Build
10:00-10:45 invited talk (gradients in vivo) - Measure
10:45-11:15 break
11:15-12:00 invited talk (reaction-diffusion systems) - Model
12:00-12:30 contributed talk
12:30-14:00 Lunch
Big question: How are mechanical cues and chemical signaling integrated?
14:00 - 14:45 Break-out discussions on sub-questions
14:45-15:30 Plenary discussion of break-out results
16:00 excursion (boat trip) and workshop dinner
Thursday September 24
Day 4
Theme: keeping time - dynamics of development
9:00-10:00 keynote (lightsheet microscopy) - Measure
10:00-10:45 invited talk (cell unmixing) - Build
10:45-11:15 break
11:15-12:00 invited talk (oscillations) - Model
12:00-12:30 contributed talk
12:30-14:00 Lunch and sponsor presentation: NIKON
14:00 – 15:30 3 contributed talks
Big question: How are developmental events timed robustly in the presence of stochastic dynamics at the single-cell level?
15:30 – 16:15 Break-out discussions on sub-questions
16:15 – 17:00 Plenary discussion of break-out results
17:00-18:00 Poster session 2
Friday September 25
Day 5
Theme: putting it all together
9:00-10:00 keynote (multiscale modeling) - Model
10:00-10:45 invited talk (multiomics) - Measure
10:45-11:15 break
11:15-12:00 invited talk (embryoids) - Build
12:00-12:30 Define and write up three new research directions that benefit from integrated approaches (in three groups)
12:30-15:30 Lunch and continue working on write-up in groups
15:30-16:00 good bye
