Integrative Developmental Biology 2020

- This workshop will be rescheduled -

21 - 25 September 2020

Venue: Lorentz Center@Oort

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Developmental biology has recently experienced a tremendous revival, due to its importance for regenerative medicine as well as powerful new methods. Progress is currently driven by recent breakthroughs in three areas: 1. the ability to quantify single-cell dynamics in embryos by novel microscopy and sequencing techniques, 2. the creation of synthetic developmental systems such as organoids and gastruloids, and 3. multiscale modeling approaches that combine biophysical and gene regulatory mechanisms. Integrating these innovations has the potential to provide a big leap forward in our understanding of development. 

 

To achieve this goal, this workshop will bring together leading researchers across model systems and approaches and help them become aware of each other’s strengths. The central goal is to define new research questions that can only be addressed with input from all areas. Alternating between presentations and group discussions, the program is designed to stimulate new collaborations and crystallize a roadmap for integrative developmental biology.

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    Monday September 21

    Integrative developmental biology – build, measure, model 

    Preliminary program 

     Day 1

    Theme: it starts with a single cell 

    9:00-10:00 registration and coffee 

    10:00 - 10:30 welcome 

    10:30-11:30 Keynote (single-cell methods) - Measure 

    11:30-12:15 Invited talk (synthetic transcription factor networks) - Build 

     

    12:15-13:30 Lunch and sponsor presentation (GenomeScan, single-cell sequencing) 

     

    13:30-14:15 Invited talk (gene regulatory networks) - Model 

    14:15-15:45 3 contributed talks 

    Big question: What is a cell type? 

    15:45 - 16:30 Break-out discussions on sub-questions 

    16:30 - 17:00 Plenary discussion of break-out results 

    17:00-19:00 Wine and cheese party

     

    The programme will be announced shortly.

    Tuesday September 22

    Day 2

    Theme: let's get together - tissues 

    9:00-10:00 keynote (gastruloids) - Build 

    10:00-10:45 invited talk (live cell tracking) - Measure 

    10:45-11:15 break 

    11:15-12:00 invited talk (agent-based modeling) - Model 

    12:00-12:30 contributed talk 

     

    12:30-14:00 Lunch and sponsor presentation (organoid culture) 

     

    14:00-15:30 3 contributed talks 

    Big question: How does tissue-level organization emerge from single-cell dynamics? 

    15:30-16:15 Break-out discussions on sub-questions 

    16:15-17:00 Plenary discussion of break-out results 

    17:00-18:00 Poster session 1

     

    The programme will be announced shortly.

    Wednesday September 23

    Day 3

    Theme: getting organized - signals, gradients, forces 

    9:00-10:00 Keynote (2D models) - Build 

    10:00-10:45 invited talk (gradients in vivo) - Measure 

    10:45-11:15 break 

    11:15-12:00 invited talk (reaction-diffusion systems) - Model 

    12:00-12:30 contributed talk 

     

    12:30-14:00 Lunch 

     

    Big question: How are mechanical cues and chemical signaling integrated? 

    14:00 - 14:45 Break-out discussions on sub-questions 

    14:45-15:30 Plenary discussion of break-out results

    16:00 excursion (boat trip) and workshop dinner

     

    The programme will be announced shortly.

    Thursday September 24

    Day 4

    Theme: keeping time - dynamics of development 

    9:00-10:00 keynote (lightsheet microscopy) - Measure 

    10:00-10:45 invited talk (cell unmixing) - Build 

    10:45-11:15 break 

    11:15-12:00 invited talk (oscillations) - Model 

    12:00-12:30 contributed talk 

     

    12:30-14:00 Lunch and sponsor presentation: NIKON 

     

    14:00 – 15:30 3 contributed talks 

    Big question: How are developmental events timed robustly in the presence of stochastic dynamics at the single-cell level? 

    15:30 – 16:15 Break-out discussions on sub-questions 

    16:15 – 17:00 Plenary discussion of break-out results 

    17:00-18:00 Poster session 2

     

    The programme will be announced shortly.

    Friday September 25

    Day 5

    Theme: putting it all together 

    9:00-10:00 keynote (multiscale modeling) - Model 

    10:00-10:45 invited talk (multiomics) - Measure 

    10:45-11:15 break 

    11:15-12:00 invited talk (embryoids) - Build 

    12:00-12:30 Define and write up three new research directions that benefit from integrated approaches (in three groups) 

    12:30-15:30 Lunch and continue working on write-up in groups 

    15:30-16:00 good bye

     

    The programme will be announced shortly.
    Please log in to view the participants information...

    Timon Idema, TU Delft  

    Nicolas Rivron, IMBA Austria  

    Anna Kicheva, IST Austria  

    Jeroen van Zon, AMOLF  

    Stefan Semrau, Leiden University  


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